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The biological responses to these materials depend on whether they release their components and whether those components are toxic

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The biological responses to these materials depend on whether they release their components and whether those components are toxic, immunogenic, or mutagenic at the released concentrations .
The biological responses to these materials depend on whether they release their components and whether those components are toxic, immunogenic, or mutagenic at the released concentrations .
So systemic and local toxicity, allergy, and carcinogenicity all result from elements in the alloy being released into the mouth during corrosion . Biological testing of the material is important in order to observe the behavioral of the material and the possible tissue responds , thus the clinician can choose the correct material with the least adverse effects on the patient

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