The biological responses to these materials depend on whether they release their components and whether those components are toxic

The biological responses to these materials depend on whether they release their components and whether those components are toxic, immunogenic, or mutagenic at the released concentrations .
The biological responses to these materials depend on whether they release their components and whether those components are toxic, immunogenic, or mutagenic at the released concentrations .
So systemic and local toxicity, allergy, and carcinogenicity all result from elements in the alloy being released into the mouth during corrosion . Biological testing of the material is important in order to observe the behavioral of the material and the possible tissue responds , thus the clinician can choose the correct material with the least adverse effects on the patient