Ergonovine is able to trigger muscles of uterine to increase level of force and frequency of contractions
Ergonovine is able to trigger muscles of uterine to increase level of force and frequency of contractions. This contractions, in usual doses precede in periods of relaxation but in in larger doses, the basal uterine tone will be elevated and will be decreasing the relaxation periods. Ergonovine is also inducer of cervical contractions. Since the uterus is more sensitive to oxytoxic effects towards the end of pregnancy, and the oxytocic actions of ergonovine are greater than its vascular effects, it can produces arterial vasoconstriction by stimulation of alpha-adrenergic and serotonin receptors and inhibition of endothelial-derived relaxation factor release. Therefore, ergonovine causes vasoconstriction of coronary arteries (“Ergonovine – DrugBank”, 2018). Adverse reactions of ergonovine however includes cardiovascular side effects, including blood pressure elevation (sometimes extreme), chest pain, dizziness, myocardial infarction, ventricular arrhythmias, bradycardia, and peripheral vasospasm, gastrointestinal side effects including nausea, vomiting, diarrhoea, and abdominal or stomach pain, hypersensitivity side effects including allergic reactions (including shock) have occurred with ergonovine. General side effects have included unpleasant taste, tinnitus, sweating, uterine cramps, and nasal congestion. Nervous system side effects have included headache (mild and transient). Respiratory side effects have included dyspnea (“Ergonovine Side Effects in Detail – Drugs.com”, 2018).